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DeCS
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Descriptor English:
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Mice, SCID
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Descriptor Spanish:
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Ratones SCID
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Descriptor Portuguese:
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Camundongos SCID
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Synonyms English:
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Immunodeficient Mice, Severe Combined
Mice, SCID-hu
Mouse, SCID
Mouse, SCID hu
Mouse, SCID-hu
SCID Mice
SCID Mouse
SCID hu Mice
SCID-hu Mice
SCID-hu Mouse
Severe Combined Immunodeficient Mice
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Tree Number:
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B01.050.150.900.649.313.992.635.505.500.550.780
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Definition English:
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Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice. |
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Indexing Annotation English:
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NIM with no qualifiers when experimental animal
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History Note English:
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92
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Allowable Qualifiers English:
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Record Number:
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29970
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Unique Identifier:
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D016513
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Occurrence in VHL:
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Similar:
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DeCS
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